Technology

Resteeme injectable bioregenerators

X-TREME TECHNOLOGY

WIDE SPECTRUM OF HA CHAIN LENGTHS
Resteeme products are based on non-cross-linked hyaluronic acid with a wide range of chain lengths that correspond to the natural component present in the body, without additional modifications.
  • Low molecular weight hyaluronic acid
    (LMW: 200–400 kDa, short chains) – stimulates fibroblast proliferation and increases synthesis of extracellular matrix proteins such as collagen and elastin.
  • Medium molecular weight hyaluronic acid
    (MMW: 1000–1500 kDa, medium chain) – moisturises the skin and speeds up regeneration processes.
  • High molecular weight hyaluronic acid
    (HMW: 1800–2600 kDa, long chains) – is responsible for biological effect, featuring antioxidant and anti-inflammatory properties. Its high viscosity and elasticity allows for modelling of the face oval and provides a lifting effect.
By combining hyaluronic acid with different chain lengths, a flexible, three-dimensional MOLECULAR STRUCTURE is formed in the skin. It stimulates and activates regenerative processes occurring in the interstitium by increasing the synthesis of collagen and elastin and providing optimal environment for proliferation and development of fibroblasts.

PATENTED COMBINATION

HYALURONIC ACID and TREHALOSE1
GLYCATION is one of the mechanisms of the physiological process of skin aging. It involves reaction of combining sugars with proteins, lipids or nucleic acids, leading to the formation of advanced glycation end products (AGEs). These advanced glycation end products initiate a sequence of reactions that accelerate the aging process. They are reflected in the skin as wrinkles, loss of elasticity, and other age-related changes.
  • HYALURONIC ACID is known not only for its stimulating effect on fibroblast proliferation, but also for its anti-inflammatory and antioxidant properties. It plays a key role in modulating the level of reactive oxygen species (ROS) and protects against oxidative damage – anti-AGEs action2.
  • TREHALOSE on the other hand, plays an important role by protecting and extending the lifespan and duration of action of endogenous and exogenous hyaluronic acid. In vitro tests showed that trehalose protects hyaluronic acid against the activity of hyaluronidase enzymes.3.
The patented combination of HYALURONIC ACID and TREHALOSE used in Resteeme X is undoubtedly a breakthrough solution used against skin aging processesNot only does it prevent from the effects of aging, but through prolonged action of HA in tissues it effectively repairs, improving the quality of the skin.
REFERENCES:
  1. Patent number US 2021/0315804 A1;
  2. Neumann A, Schinzel R, Palm D, Riederer P, Münch G. High molecular weight hyaluronic acid inhibits advanced glycation endproduct-induced NF-kB activation and cytokine expression. FEBS letters. 1999;453(3):283-287;
  3. Complife Study Report E.IT.076 _2018/2116 B "EVALUATION OF THE SUSCEPTIBILITY OF A HYALURONATE-BASED PRODUCT TO THE ACTIVITY OF HYALURONIDASE";