GLYCATION

ONE OF THE MECHANISMS OF SKIN AGEING
One of the mechanisms of the physiological skin ageing where sugars bind with proteins, lipids or nucleic acids, leading to the formation of AGEs (advanced glycation end products).
Glycation process diagram
  • AGEs alter the physical and biological properties of extracellular matrix proteins, in particular collagen, elastin and GAGs; their accumulation leads to significant modifications in the skin structure and function6.
  • AGEs disrupt NF-κB7 functions — causing chronic inflammation. They accelerate ageing and exacerbate chronic diseases as they accumulate and trigger a cascade of reactions which damage structural proteins such as collagen and elastin.

COMPREHENSIVE

ANTI-GLYCATION THERAPY*
Anti-AGEs action on all layers of the skin.

Skin structures susceptible to glycation, including structural proteins such as collagen, elastin, and skin cells, which are particularly vulnerable to the glycation process.
Anti-AGEs action on all layers of the skin
* Procedures involving Resteeme injection treatments.

EFFECT OF A.G.E. REVERSING COMPLEX

ON GLYCATED FIBROBLASTS
Effect of A.G.E. Reversing complex on glycated fibroblasts
In glycated fibroblast cultures, A.G.E. Reversing complex significantly reduced AGEs accumulation, namely CML adducts (-85%): permanent bonds between protein molecules and the advanced glycation end products (AGEs).

Moreover, it repaired the glycation effect on vimentin, restoring fibroblasts to their normal, composite shape.

FULL ANTI-GLYCATION

PROTOCOL*
Complete therapy combining injection treatments with daily anti-glycation, anti-AGEs home care.
Full anti-glycation protocol
* Procedures involving Resteeme injection treatments.

THERAPEUTIC EFFECT

AFTER THE FULL TREATMENT PROTOCOL COMBINED WITH HOME CARE
Before treatment
BEFORE
After treatment
AFTER TREATMENTS WITH Resteeme X+L+L
+ Resteeme AGE REVERSE home care
Enhanced effectiveness of Resteeme treatment protocol thanks to its combination with Resteeme AGE REVERSE, home care, applied solely on the right side of the face*.
Skin parameter improvements - case 1
Before treatment
BEFORE
After treatment
AFTER TREATMENTS WITH Resteeme X+L+L
+ Resteeme AGE REVERSE home care
Skin parameter improvements - case 2
* Assessment of specific skin parameters in Visia analyser.

RESTEEME AGE REVERSE

REDEFINING SERUM — 28 ml

PROVEN EFFECTIVENESS*

  • +42% Intensively moisturizes
  • +24% Reduces wrinkle volume
  • +20% Reduces surface area of wrinkles

MAIN ACTIVE INGREDIENTS

  • A.G.E. Reversing complex reverses glycation processes and reduces oxidative stress. It breaks down existing AGEs, restoring the normal properties of collagen and elastin fibers.
  • Trehalose protects proteins and lipids and shows active anti-glycation effects. It stabilizes the cell matrix and delays the formation of AGEs.
  • Full Spectrum HA+ (full spectrum hyaluronic acids) rebuilds and protects the extracellular matrix from glycation.
  • RNA/DNA Polynucleotides support cell division and skin cell repair, protecting fibroblasts from damages caused by AGEs.
  • Niacinamide — a powerful antioxidant that helps brighten the skin.

DIRECTIONS FOR USE

Use daily in the morning and evening.

RESULTS CONFIRMED BY USERS**

  • 100% visibly firmer, smoother, and more toned skin
  • 100% an improvement in skin elasticity, softness
  • 100% immediate and long-lasting hydration and restored skin comfort
  • 100% visible improvement in skin tone and revitalization
Resteeme AGE REVERSE Redefining Serum 28 ml
* Report on instrumental test study after 4 weeks product usage. No. K/0/07/2025/248/F/NN/2 GBA Polska Sp. z o.o.
** Report on application test & consumer evaluation after 8 weeks product usage. No. K/0/07/2025/248/F/NN/2 GBA Polska Sp. z o.o.

RESTEEME AGE REVERSE

REDEFINING CREAM — 50 ml

PROVEN EFFECTIVENESS*

  • +36% Firms the skin
  • +30% Increases skin elasticity
  • +23% Reduces the volume of wrinkles

MAIN ACTIVE INGREDIENTS

  • A.G.E. Reversing complex reverses glycation processes and reduces oxidative stress. It breaks down existing AGEs, restoring the normal properties of collagen and elastin fibers.
  • Trehalose protects proteins and lipids and shows active anti-glycation effects. It stabilizes the cell matrix and delays the formation of AGEs.
  • Full Spectrum HA+ (full spectrum hyaluronic acids) rebuilds and protects the extracellular matrix from glycation.
  • RNA/DNA Polynucleotides support cell division and skin cell repair, protecting fibroblasts from damages caused by AGEs.
  • Shea butter & Macadamia seed oil — restore ceramides and rebuild the hydrolipidic barrier.

DIRECTIONS FOR USE

Use daily in the morning and evening.

RESULTS CONFIRMED BY USERS**

  • 100% visibly firmer, smoother, and more toned skin
  • 100% more elastic, soft, smooth, and radiant
  • 100% immediate hydration and improvement in skin appearance
  • 100% noticeable improvement in skin tone and revitalization
Resteeme AGE REVERSE Redefining Cream 50 ml
* Report on instrumental test study after 4 weeks product usage. No. K/0/07/2025/248/F/NN/2 GBA Polska Sp. z o.o.
** Report on application test & consumer evaluation after 8 weeks product usage. No. K/0/07/2025/248/F/NN/2 GBA Polska Sp. z o.o.

EVERYDAY ANTI-GLYCATION HOME CARE

A.G.E. Reversing complex

Innovative complex to reverse glycation processes (anti-AGEs action) and reduce oxidative stress. Its active ingredients break down existing AGEs, reducing stiffness and damage to collagen and elastin, and restoring biomechanical functions of the skin.

Full Spectrum HA+

Full spectrum of Hyaluronic Acids stabilized with trehalose.

  • INCREASED SKIN DENSITY, RESTORED ELASTICITY
  • REDUCED WRINKLE VOLUME AND SURFACE
  • IMMEDIATE HYDRATION AND STRONGER HYDROLIPID BARRIER
Data on file: A.G.E Reversing complex:
  1. Effect on skin elastic recovery; In tubo test: Deglycating effect on isolated human glycated collagen. Decrease in CML adducts in solution of glycated human collagen.
  2. In vitro test: Effect on CML adducts contained in glycated fibroblasts culture. Intracellular CML quantification in glycated fibroblasts after incubation with formula; Effect on CML adducts and vimentin protein distribution in skin glycated fibroblasts culture.

RETIX.C/EXP/BR/2025/10/01 — Promotional content for professionals.
URGO Sp. z o.o., Al. Jerozolimskie 142 B, 02-305 Warsaw, mobile +48 519 140 997